QuanticSphere™ | High-Bioavailability Delivery Platform
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Next-Gen Phytosome Quantum Nano Sphere for Advanced Bioactive Delivery

A cationic phospholipid vesicle system engineered to improve solubility, stability, absorption, and gut tolerance for minerals, vitamins, botanicals, and key bioactives.

WHY QuanticSphere™

Protection, Precision, and Programmable Release

Designed to mirror biological membranes and optimize cellular uptake while reducing GI irritation.

Enhanced Solubility

Encapsulation improves dissolution of low-solubility actives and shields them from degradation.

Targeted Uptake

Surface charge and ligand options promote membrane interaction and receptor-mediated delivery.

Gut-Friendly Profile

Vesicular barrier reduces direct ion contact with the intestinal lining for better tolerability.

3D model of QuanticSphere™ (PQNS) nanosphere showing cationic phospholipid bilayer, hydrophilic head and tail, and encapsulated vitamins and botanicals for superior bioavailability
Mechanism

Phytosome Quantum Nano Sphere (PQNS)

  • Encapsulation: Bioactives loaded in an aqueous core or bilayer for stability and controlled exposure.
  • Positive Surface Charge: Promotes electrostatic interactions with enterocyte membranes and uptake.
  • Multiple Entry Paths: Membrane fusion, passive diffusion, endocytosis, and receptor-mediated routes.
  • Shielding: Protects contents from gastric acidity and enzymatic degradation for higher effective delivery.
Baseline Bioavailability

Where QuanticSphere™ Can Help Most

Selected ingredients with typically low raw bioavailability—ideal candidates for PQNS formulation.

CategoryExamplesRaw Bioavailability
BotanicalsCurcumin, Resveratrol, Quercetin, EGCGVery low
MineralsIronLow
VitaminsVitamin K1/K2Moderate
Other BioactivesCoQ10, Omega-3 (EPA/DHA)Very low

Note: Values represent typical ranges for raw actives prior to PQNS enhancement.

3D illustration showing QuanticSphere™ (PQNS) cationic nanospheres interacting with the intestinal cell membrane to enhance nutrient absorption and cellular uptake

Why QuanticSphere™

Clinically-minded delivery that patients tolerate

Superior Tolerability

Reduces gastrointestinal irritation vs. conventional supplements.

Improved Absorption

Phospholipid encapsulation enhances nutrient solubility.

Increased Bioavailability

PQNS boosts systemic uptake up to ~85–90%.

Biocompatibility & Safety

Mimics natural cell membranes for gut-friendly delivery.

Controlled Release

Ensures steady nutrient levels and reduced dosing frequency.

Gallery

Visualizing the Platform

PQNS concept image 1
PQNS concept image 2
PQNS concept image 3
Get the Technical Details

Ready to evaluate QuanticSphere™ for your formula?

Request the technical deck, CoAs, and a feasibility discussion with our R&D.

Contact R&D
Contact

Speak with Formulation Science

We’ll share a technical deck, example formulations, and timelines for pilot lots.

© Crassula™ · QuanticSphere™ Technology (Patent No:202521095813) · All rights reserved. A technology of Crassula Pharmaceuticals.