QuanticSphere™ PQNS Technology | Advanced Bioactive Delivery | Crassula
Crassula Pharmaceuticals · Dr. Bhawana Gupta, PhD (Biotechnology)

PQNS™
Phytosome Quantum
Nano Sphere

Next-generation cationic phospholipid-based nanovesicular delivery system for minerals, vitamins, and botanicals — engineered for superior bioavailability, precision delivery, and clinical performance.

“Precision science. Smart delivery. Total protection. Proven performances.”

August 2025
Dr. Bhawana Gupta, PhD
Technical White Paper
QuanticSphere PQNS nanoparticle delivery system
PQNS
Phytosome Quantum
Nano Sphere Technology
3P
Protection · Programmability
Precision Delivery
300+
Bioactives with Low
Conventional Bioavailability
Comparative Attributes
vs Liposomes & Standard

Overcoming the Limitations of
Conventional Supplementation

The limited absorption and instability of bioactive supplements in the gastrointestinal tract have long presented challenges in nutrition science. QuanticSphere™ introduces a transformative delivery strategy based on cationic phospholipid vesicular technology.

Abstract

QuanticSphere™ PQNS represents a next-generation delivery system engineered to overcome the limitations of conventional mineral and nutraceutical supplementation.

By utilizing cationic phospholipid vesicular technology, PQNS enhances solubility, bioavailability, and stability of bioactive compounds while reducing gastrointestinal side effects.

This document provides a technical, clinical, and comparative overview of PQNS technology and its applications.

Prepared byDr. Bhawana Gupta, PhD (Biotechnology) — Crassula Pharmaceuticals Pvt. Ltd. — August 2025
Introduction

QuanticSphere™ PQNS is a cutting-edge system of spherical vesicles composed of one or more phospholipid bilayers. These vesicles encapsulate mineral compounds and bioactive agents, protecting them from enzymatic degradation and acidic hydrolysis.

By mimicking the structural and functional characteristics of cellular membranes, PQNS facilitates efficient cellular penetration and intracellular delivery — significantly improving solubility and absorption.

The result: multifold bioavailability improvement over conventional formulations across minerals, vitamins, botanicals, and bioactives.

How PQNS Achieves
Multifold Bioavailability

QuanticSphere™’s dual polar–nonpolar architecture simultaneously boosts solubility and facilitates direct intracellular delivery — bypassing traditional absorption barriers.

Superior Bioavailability
Enhanced Solubility & Stability
Dual polar–nonpolar structure boosts solubility of challenging nutrients and safeguards them from degradation through advanced encapsulation.
Gut-Friendly Profile
Promotes gut comfort by safely enclosing actives in a lipid layer that minimizes irritation and harsh contact with the gut wall.
Facilitated Cellular Uptake
Direct Intracellular Delivery
Mimics cellular membranes, seamlessly fusing with them to deliver bioactives directly into the cytoplasm — bypassing traditional absorption barriers.
Controlled & Sustained Release
Engineered for gradual, sustained release — maintaining optimal nutrient levels in the body while reducing the need for frequent dosing.
Optimized Dosing
Smaller effective doses due to superior absorption kinetics and sustained release
Controlled Release
Programmable sustained release maintains optimal plasma concentrations throughout the day
Biocompatibility & Safety
Phospholipid composition mirrors biological membranes for maximum compatibility and tolerability
Increased Bioavailability
Receptor-mediated uptake and improved solubility deliver multifold bioavailability improvements
Improved Absorption
Transcellular and paracellular transport routes maximize gastrointestinal uptake
Superior Tolerability
Protective lipid bilayer eliminates GI irritation associated with conventional high-dose supplements

Three Areas Where
PQNS Delivers Superiority

QuanticSphere™ technology is applicable across a broad spectrum of nutritional and clinical scenarios — addressing deficiencies, chronic conditions, and enabling synergistic multi-compound therapies.

1
Nutrient deficiencies — PQNS mineral vitamin delivery
Nutrient Deficiency Replenishment
QuanticSphere™ is highly effective for the rapid replenishment of nutrients that suffer from low bioavailability in conventional forms.
Iron · Magnesium · Zinc B12 · Folate · D · K2 Curcumin · CoQ10 Omega-3 EPA/DHA
2
Chronic conditions — impaired nutrient absorption PQNS
Chronic Conditions & Impaired Absorption
QuanticSphere™ is beneficial for individuals with impaired nutrient absorption — bypassing compromised intestinal barriers to deliver actives directly at the cellular level.
Celiac Disease Inflammatory Bowel Malabsorption
3
Synergistic combination therapy — co-encapsulation PQNS
Synergistic Combination Therapy
QuanticSphere™ enables co-encapsulation of multiple supplements for multi-targeted therapy addressing inflammation, metabolic disorders, and cardiovascular protection.
Curcumin + Resveratrol Vitamin D + K2 Multi-target therapy
QuanticSphere PQNS laboratory — pharmaceutical research

Redefining the Standard of
Mineral & Botanical Delivery

QuanticSphere™ redefines the standard of mineral, vitamin, and botanical supplementation. Through PQNS technology, it integrates protection, programmability, and precision delivery into a robust platform.

Enhanced Absorption
Multifold improvement in bioavailability over conventional formulations across all nutrient categories.
Minimized Side Effects
Protective bilayer architecture eliminates GI irritation, improving patient tolerance and compliance.
Lower Effective Doses
Superior cellular retention reduces the required dose to achieve the same or greater biological effect.
Fully Programmable Release
Sustained, controlled release kinetics maintain optimal plasma concentrations throughout the day.
QuanticSphere™ establishes itself as a superior next-generation solution for both nutritional and clinical applications — integrating protection, programmability, and precision delivery into a single robust platform.

Ingredients with Low
Conventional Bioavailability

Key nutrients that benefit most from PQNS delivery technology due to their inherently poor absorption profiles in standard formulations.

Very Low <10%
Low 10–20%
Moderate 20–50%
Vitamins
Low Bioavailability
Vitamin A (β-carotene)
Moderate Bioavailability
Vitamin E (α-Tocopherol), Vitamin B12, Vitamin K (K1/K2)
Minerals
Low Bioavailability
Iron
Moderate Bioavailability
Calcium, Zinc, Magnesium
Botanicals
Very Low Bioavailability
Black Cohosh, Cranberry, Curcumin longa, Damiana, Ginseng, Silymarin, Boswellia, Resveratrol, Quercetin, Green Tea, Elderberry, Lion’s Mane
Low Bioavailability
Ashwagandha, Saw Palmetto, Rhodiola, Echinacea, Evening Primrose, Fenugreek, Ginkgo Biloba, Hops, Garlic
Bioactives
Very Low Bioavailability
CoQ10, Alpha Lipoic Acid, Lutein, Zeaxanthin, Astaxanthin, Berberine, EGCG, AKBA
Low Bioavailability
Glutathione, Curcuminoids, Allicin
Moderate Bioavailability
Sulforaphane (from Broccoli)

PQNS vs Liposomes vs
Conventional Supplements

A comprehensive feature comparison demonstrating the clear clinical and technological superiority of QuanticSphere™ PQNS over established delivery technologies.

Feature / Attribute PQNS (QuanticSphere™) Liposomes Conventional
BioavailabilityVery high (programmable release, receptor-mediated uptake, improved solubility)Moderate (variable, depends on stability and size)Low (limited solubility and poor absorption)
StabilitySuperior protection against gastric acidity & enzymatic degradationModerate stability, prone to oxidation or fusionPoor stability; rapid degradation in GI tract
Precision DeliveryTargeted delivery, direct intracellular transportCreates barrier for cellular processesNo targeting; relies on bulk absorption
Gut ToleranceGut-friendly (reduced irritation due to protective bilayer)Gut-friendlyFrequently associated with irritation
Dose EfficiencyRequires smaller doses due to superior absorption & sustained releaseModerateHigh doses required for effect
ProgrammabilityFully programmable (sustained release, co-encapsulation for synergy)Limited control over release kineticsNone; immediate release only
Synergistic TherapyEnables co-encapsulation (e.g., Vitamin D + K2, Curcumin + Resveratrol)PossibleNot feasible; separate products needed
Clinical AdvantageNext-generation platform: protection, programmability, precisionEstablishedTraditional; limited efficacy

Precision Science.
Smart Delivery. Total Protection.

QuanticSphere™ PQNS represents the future of bioactive delivery — a robust platform integrating protection, programmability, and precision to deliver superior nutritional and clinical outcomes across minerals, vitamins, and botanicals.

Contact the Medical Team