Nopyre Infusion® (Paracetamol) – Crassula
Non-Opioid Analgesic and Antipyretic · Intravenous Infusion

Nopyre Infusion®

Paracetamol

1000 mg / 100 mL
Nopyre Infusion paracetamol 1000 mg / 100 mL box
  • Active ingredient
    Paracetamol BP
  • Strength
    1 g / 100 mL
  • Presentation
    1 vial of 100 mL
  • Standard
    BP

What is Nopyre Infusion?

NOPYRE INFUSION is a ready-to-use paracetamol solution for intravenous infusion, indicated for short-term treatment of moderate pain and fever when intravenous administration is clinically justified.

info nopyre

Indications

For short-term treatment when an urgent need to treat pain or fever exists and other routes of administration are not possible.

Moderate Pain

Short-term treatment of moderate pain, especially following surgery.

Fever

Short-term treatment of fever when intravenous administration is clinically justified.

When Oral Route Is Not Possible

A ready-to-use intravenous option when other routes of administration are not possible.

Adults and Patients Over 33 kg

The 100 mL presentation is for adults, adolescents and children weighing more than 33 kg.

Presentation

1 Vial
100 mL glass vial
Strength
1000 mg / 100 mL
Route
Intravenous infusion
Shelf life
36 months

Pharmacological Properties

The precise mechanism of paracetamol analgesic and antipyretic action has not been fully established; it may involve central and peripheral actions.

How Nopyre Infusion works

Nopyre Infusion®Paracetamol Central and Peripheral Analgesic Actions Pain Relief and Fever Reduction Analgesic and Antipyretic Effect

Dosage and Administration

  • For patients weighing more than 50 kg without additional hepatotoxicity risk factors: 1 g (100 mL) per administration; maximum 4 g daily.
  • Administer as a slow intravenous infusion over at least 15 minutes.
  • Observe a minimum interval of 4 hours between administrations; increase to 6 hours in severe renal insufficiency.

Benefits and Clinical Considerations

Onset of Action

Pain relief begins within 5 to 10 minutes after the start of administration; peak analgesic effect is obtained in 1 hour.

Duration

The analgesic effect usually lasts 4 to 6 hours; antipyretic effect begins within 30 minutes and lasts at least 6 hours.

Safety and Precautionary Measures

Avoid Overdose

Check that other medicines administered do not contain paracetamol. Dosing errors between mg and mL may lead to accidental overdose.

Contraindications and Caution

Contraindicated in severe hepatocellular insufficiency or hypersensitivity to paracetamol. Use caution in hepatic impairment, severe renal impairment, chronic alcoholism, malnutrition or dehydration.

Frequently Asked Questions

NOPYRE INFUSION is a ready-to-use paracetamol solution for intravenous infusion, indicated for short-term treatment of moderate pain and fever when intravenous administration is clinically justified.

For short-term treatment when an urgent need to treat pain or fever exists and other routes of administration are not possible. It is indicated for the short-term treatment of moderate pain, especially following surgery, and the short-term treatment of fever when intravenous administration is clinically justified. The 100 mL presentation is for adults, adolescents and children weighing more than 33 kg.

The precise mechanism of paracetamol analgesic and antipyretic action has not been fully established; it may involve central and peripheral actions.

For patients weighing more than 50 kg without additional hepatotoxicity risk factors: 1 g (100 mL) per administration; maximum 4 g daily. Administer as a slow intravenous infusion over at least 15 minutes. Observe a minimum interval of 4 hours between administrations; increase to 6 hours in severe renal insufficiency.

Pain relief begins within 5 to 10 minutes after the start of administration; peak analgesic effect is obtained in 1 hour. The analgesic effect usually lasts 4 to 6 hours; antipyretic effect begins within 30 minutes and lasts at least 6 hours.

Check that other medicines administered do not contain paracetamol. Dosing errors between mg and mL may lead to accidental overdose. Contraindicated in severe hepatocellular insufficiency or hypersensitivity to paracetamol. Use caution in hepatic impairment, severe renal impairment, chronic alcoholism, malnutrition or dehydration.

Each 100 mL glass vial contains 1000 mg of paracetamol (1 g / 100 mL) for intravenous infusion. The shelf life is 36 months.

Each 100 mL vial contains paracetamol BP 1 g in a clear and colourless infusion solution. The finished-product specification includes assay, particulate matter, bacterial endotoxins and sterility testing. Crassula Pharma certifies that all our products are manufactured in accordance with GMP parameters.

Quality and Standards

GMP Certified Quality

Each 100 mL vial contains paracetamol BP 1 g in a clear and colourless infusion solution. The finished-product specification includes assay, particulate matter, bacterial endotoxins and sterility testing.