{"id":11984,"date":"2026-10-21T11:32:12","date_gmt":"2026-10-21T15:32:12","guid":{"rendered":"https:\/\/crassulapharma.com\/?page_id=11984"},"modified":"2026-10-21T11:50:12","modified_gmt":"2026-10-21T15:50:12","slug":"novapyr","status":"publish","type":"page","link":"https:\/\/crassulapharma.com\/es\/novapyr\/","title":{"rendered":"Novapyr"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"11984\" class=\"elementor elementor-11984\" data-elementor-post-type=\"page\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9bfee20 e-con-full e-flex e-con e-parent\" data-id=\"9bfee20\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a43c84e elementor-widget elementor-widget-html\" data-id=\"a43c84e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<!doctype html>\n<html lang=\"en\">\n<head>\n<meta charset=\"utf-8\">\n<meta name=\"viewport\" content=\"width=device-width, initial-scale=1\">\n<title>Novapyr\u00ae (Metamizole sodium) \u2013 Crassula<\/title>\n<meta name=\"description\" content=\"Novapyr 1g\/2ml is an injectable solution of Metamizole Sodium, presented in OPC (One-Point-Cut) ampoules for intramuscular (IM) and intravenous (IV) administration.\">\n<link rel=\"preload\" href=\"fonts\/poppins-latin-600-normal.woff2\" as=\"font\" type=\"font\/woff2\" crossorigin>\n<link rel=\"preload\" href=\"fonts\/ibm-plex-sans-latin-400-normal.woff2\" as=\"font\" type=\"font\/woff2\" crossorigin>\n<style>\n@font-face{font-family:\"Poppins\";font-weight:500;font-style:normal;font-display:swap;src:url(fonts\/poppins-latin-500-normal.woff2) format(\"woff2\")}\n@font-face{font-family:\"Poppins\";font-weight:600;font-style:normal;font-display:swap;src:url(fonts\/poppins-latin-600-normal.woff2) format(\"woff2\")}\n@font-face{font-family:\"IBM Plex Sans\";font-weight:400;font-style:normal;font-display:swap;src:url(fonts\/ibm-plex-sans-latin-400-normal.woff2) format(\"woff2\")}\n@font-face{font-family:\"IBM Plex Sans\";font-weight:500;font-style:normal;font-display:swap;src:url(fonts\/ibm-plex-sans-latin-500-normal.woff2) format(\"woff2\")}\n\n:root{\n  --teal-deep:#09342e; --teal-head:#0f4a3e; --teal:#157c65; --teal-2:#21856e; --teal-3:#0f4a3e;\n  --red:#c98a3f; --accent-text:#9a6420; --green:#3da184;\n  --action-teal:#157c65; --ink:#0f2f25; --ink-muted:#4a665a; --surface:#f3f8f5; --note:#f3f8f5;\n  --line:#dfeae4;\n  --ease-out:cubic-bezier(.23,1,.32,1);\n  --font-head:\"Poppins\",system-ui,sans-serif;\n  --font-body:\"IBM Plex Sans\",system-ui,sans-serif;\n  --cx-gutter:clamp(20px,5vw,48px);\n  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dd{overflow-wrap:break-word}\n[type=\"button\"]:hover{background-color:transparent;color:var(--teal-head)}\n[type=\"button\"]:focus{background-color:transparent;color:var(--teal-head)}\n<\/style>\n<script type=\"application\/ld+json\">{\"@context\": \"https:\/\/schema.org\", \"@type\": \"FAQPage\", \"mainEntity\": [{\"@type\": \"Question\", \"name\": \"What is Novapyr?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Novapyr 1g\/2ml (Metamizole Sodium) for Intramuscular and Intravenous Use with OPC Ampoule. Novapyr 1g\/2ml is an injectable solution of Metamizole Sodium, presented in OPC (One-Point-Cut) ampoules for intramuscular (IM) and intravenous (IV) administration. This analgesic and antipyretic is highly effective for the management of severe pain and the control of high fevers, particularly in situations where other treatments have not been effective.\"}}, {\"@type\": \"Question\", \"name\": \"What is Novapyr indicated for?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Metamizole 1g\/2ml is indicated for the treatment of: severe acute pain (postoperative, post-traumatic, renal colic and biliary colic), cancer pain (management of pain associated with oncological diseases) and high fever that does not respond to other antipyretics.\"}}, {\"@type\": \"Question\", \"name\": \"How does Novapyr work?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Metamizole is a pyrazolone derivative with potent analgesic and antipyretic effects. It acts by inhibiting the synthesis of prostaglandins and other mediators of pain and fever in the central and peripheral nervous system.\"}}, {\"@type\": \"Question\", \"name\": \"How is Novapyr dosed and administered?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"For adults and adolescents over 15 years: 1g of Metamizole administered IM or IV. The dose may be repeated every 6 to 8 hours as needed, not exceeding 4g\/day. For intravenous administration, inject very slowly, at a rate not exceeding 1 mL per minute. OPC ampoules should be opened at a predetermined point, ensuring safer and more efficient opening.\"}}, {\"@type\": \"Question\", \"name\": \"What are the New OPC Ampoules?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Reduced particle emission upon opening. Enamel flakes from the ceramic rings can no longer fall into the medication. Cleaner break appearance, reduced risk of sharp glass spikes when opening, reducing the risk of injury. Significant reduction in the risk of ampoules that are very difficult to open.\"}}, {\"@type\": \"Question\", \"name\": \"What are the clinical considerations for Novapyr?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Use with caution in patients with a history of allergies to analgesics. Monitor blood pressure during intravenous administration, as it may cause hypotension. Avoid in patients with acute hepatic porphyria, glucose-6-phosphate dehydrogenase deficiency, a history of metamizole-induced agranulocytosis, impaired bone marrow function, or diseases of the hematopoietic system.\"}}, {\"@type\": \"Question\", \"name\": \"What are the safety and precautionary measures for Novapyr?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"If symptoms of agranulocytosis occur, discontinue treatment and perform a blood count immediately. Caution in patients with renal or hepatic disease. Contraindicated in patients during the third trimester of pregnancy and in those with hypersensitivity to metamizole.\"}}, {\"@type\": \"Question\", \"name\": \"Which strength and presentation is available?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Novapyr contains Metamizole sodium BP 1 G \/ 2 ml. It is presented in a box of 10 and 100 ampoules, following the British Pharmacopoeia standard.\"}}, {\"@type\": \"Question\", \"name\": \"How is Novapyr manufactured?\", \"acceptedAnswer\": {\"@type\": \"Answer\", \"text\": \"Manufactured according to the strict specifications of the British Pharmacopoeia to ensure consistency and superior quality. Crassula Pharma certifies that all our products are manufactured in accordance with GMP parameters.\"}}]}<\/script>\n<\/head>\n<body class=\"no-js\">\n<a class=\"skip\" href=\"#main\">Skip to content<\/a>\n<span id=\"top\"><\/span>\n\n\n<main id=\"main\">\n<section class=\"hero\" aria-labelledby=\"h1\" style=\"padding:0\">\n  <canvas id=\"fx\" aria-hidden=\"true\"><\/canvas>\n  <div class=\"cx-wrap\">\n    <div class=\"hero-copy\">\n      <span class=\"tag\">Analgesic \u00b7 Antipyretic \u00b7 Injectable Solution I.M. \/ I.V.<\/span>\n      <h1 id=\"h1\">Novapyr<sup>\u00ae<\/sup><\/h1>\n      <p class=\"generic\">Metamizole sodium<\/p>\n      <div class=\"strengths\" role=\"list\">\n        <span class=\"chip g\" role=\"listitem\">1G \/ 2 ml<\/span>\n      <\/div>\n      <div class=\"cta-row\">\n        <a class=\"btn btn-primary\" href=\"#mechanism\">Pharmacological Properties<\/a>\n      <\/div>\n    <\/div>\n    <div class=\"hero-art\">\n      <img fetchpriority=\"high\" decoding=\"async\" src=\"https:\/\/crassulapharma.com\/wp-content\/uploads\/2026\/10\/box-novapyr.png\" alt=\"Novapyr metamizole sodium 1 G \/ 2 ml box\" width=\"1005\" height=\"590\" title=\"\">\n    <\/div>\n  <\/div>\n<\/section>\n\n<div class=\"specs\">\n  <div class=\"cx-wrap\">\n    <ul>\n      <li><span class=\"ico\"><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\"><rect x=\"2.5\" y=\"8\" width=\"19\" height=\"8\" rx=\"4\"\/><path d=\"M12 8v8\"\/><\/svg><\/span><dl><dt>Active ingredient<\/dt><dd>Metamizole sodium BP<\/dd><\/dl><\/li>\n      <li><span class=\"ico\"><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\"><path d=\"M12 12c-2-3-3.5-4-5.5-4a4 4 0 0 0 0 8c2 0 3.5-1 5.5-4Zm0 0c2 3 3.5 4 5.5 4a4 4 0 0 0 0-8c-2 0-3.5 1-5.5 4Z\"\/><\/svg><\/span><dl><dt>Strength<\/dt><dd>1 G \/ 2 ml<\/dd><\/dl><\/li>\n      <li><span class=\"ico\"><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\"><path d=\"M21 8 12 3 3 8v8l9 5 9-5V8Z\"\/><path d=\"m3 8 9 5 9-5M12 13v8\"\/><\/svg><\/span><dl><dt>Presentation<\/dt><dd>Box of 10 and 100 ampoules<\/dd><\/dl><\/li>\n      <li><span class=\"ico\"><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\"><rect x=\"5\" y=\"3\" width=\"14\" height=\"18\" rx=\"3\"\/><path d=\"M9 8h6M9 12h6M9 16h3\"\/><\/svg><\/span><dl><dt>Standard<\/dt><dd>British Pharmacopoeia<\/dd><\/dl><\/li>\n    <\/ul>\n  <\/div>\n<\/div>\n\n<section class=\"about\" aria-labelledby=\"what\">\n  <div class=\"cx-wrap split\">\n    <div class=\"prose rv\">\n    <h2 class=\"h2\" id=\"what\">What is Novapyr?<\/h2>\n    <p><strong>Novapyr<\/strong> 1g\/2ml (Metamizole Sodium) for Intramuscular and Intravenous Use with OPC Ampoule<\/p>\n    <h3 class=\"subh\">Product Description<\/h3>\n    <p>Novapyr 1g\/2ml is an injectable solution of Metamizole Sodium, presented in OPC (One-Point-Cut) ampoules for intramuscular (IM) and intravenous (IV) administration. This analgesic and antipyretic is highly effective for the management of severe pain and the control of high fevers, particularly in situations where other treatments have not been effective.<\/p>\n    <\/div>\n    <div class=\"media-wrap rv\" style=\"--d:1\"><div class=\"media\"><img loading=\"lazy\" src=\"https:\/\/crassulapharma.com\/wp-content\/uploads\/2026\/10\/info-novapyr.jpg\" alt=\"\" width=\"1600\" height=\"1200\" loading=\"lazy\" decoding=\"async\" title=\"\"><\/div><\/div>\n  <\/div>\n<\/section>\n\n<section class=\"indications\" id=\"indications\" aria-labelledby=\"ind\">\n  <div class=\"cx-wrap\">\n    <h2 class=\"h2 rv\" id=\"ind\">Indications<\/h2>\n    <p class=\"lead rv\">Metamizole 1g\/2ml is indicated for the treatment of:<\/p>\n    <div class=\"cards c3\">\n      <article class=\"card rv\" style=\"--d:0\">\n        <div class=\"card-h\"><span class=\"ico\"><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\"><path d=\"M13 2 4 14h7l-1 8 9-12h-7l1-8Z\"\/><\/svg><\/span><h3>Severe Acute Pain<\/h3><\/div>\n        <p>Postoperative, post-traumatic, renal colic and biliary colic.<\/p>\n      <\/article>\n      <article class=\"card rv\" style=\"--d:1\">\n        <div class=\"card-h\"><span class=\"ico\"><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\"><path d=\"M12 3 4 6v6c0 4.500 3.400 7.800 8 9 4.600-1.200 8-4.500 8-9V6l-8-3Z\"\/><path d=\"m9 12 2 2 4-4\"\/><\/svg><\/span><h3>Cancer Pain<\/h3><\/div>\n        <p>Management of pain associated with oncological diseases.<\/p>\n      <\/article>\n      <article class=\"card rv\" style=\"--d:2\">\n        <div class=\"card-h\"><span class=\"ico\"><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\"><path d=\"M10 4a2 2 0 0 1 4 0v10.500a4 4 0 1 1-4 0V4Z\"\/><path d=\"M12 9v7\"\/><\/svg><\/span><h3>High Fever<\/h3><\/div>\n        <p>That does not respond to other antipyretics.<\/p>\n      <\/article>\n    <\/div>\n  <\/div>\n<\/section>\n\n<section class=\"presentations\" id=\"presentations\" aria-labelledby=\"pres\">\n  <div class=\"cx-wrap\">\n    <h2 class=\"h2 rv\" id=\"pres\">Presentation<\/h2>\n    <article class=\"pcard wide rv\" style=\"--c:#c98a3f\">\n      <div class=\"dose\">1 G<small>\/ 2 ml<\/small><\/div>\n      <dl class=\"pgrid\">\n        <div><dt>Active ingredient<\/dt><dd>Metamizole sodium BP 1 G \/ 2 ml<\/dd><\/div>\n        <div><dt>Presentation<\/dt><dd>Box of 10 and 100 ampoules<\/dd><\/div>\n        <div><dt>Standard<\/dt><dd>British Pharmacopoeia<\/dd><\/div>\n      <\/dl>\n    <\/article>\n  <\/div>\n<\/section>\n\n<section id=\"mechanism\" aria-labelledby=\"moa\">\n  <div class=\"cx-wrap\">\n    <h2 class=\"h2 rv\" id=\"moa\">Pharmacological Properties<\/h2>\n    <div class=\"mech-grid\">\n      <ol class=\"steps\" id=\"steps\">\n        <li class=\"rv\"><span class=\"num\">1<\/span><h3>Pyrazolone Derivative<\/h3><p>Metamizole is a pyrazolone derivative with potent analgesic and antipyretic effects.<\/p><\/li>\n        <li class=\"rv\"><span class=\"num\">2<\/span><h3>Central and Peripheral Action<\/h3><p>It acts by inhibiting the synthesis of prostaglandins and other mediators of pain and fever in the central and peripheral nervous system.<\/p><\/li>\n      <\/ol>\n\n      <div class=\"flow\" id=\"flow\" role=\"group\" aria-label=\"How Novapyr works\">\n        <p class=\"flow-title\">How Novapyr works<\/p>\n        <span class=\"node primary\" style=\"--i:0\">Novapyr\u00ae<small>Metamizole sodium<\/small><\/span>\n        <div class=\"link-v stop\" style=\"--i:1\"><\/div>\n        <span class=\"node\" style=\"--i:2\"><b>Prostaglandins &amp;<\/b><small>pain \/ fever mediators<\/small><\/span>\n        <div class=\"link-v\" style=\"--i:3\"><\/div>\n        <span class=\"node\" style=\"--i:4\"><b>Central &amp; peripheral<\/b><small>nervous system<\/small><\/span>\n        <div class=\"fork\" style=\"--i:5\"><i><\/i><i><\/i><\/div>\n        <div class=\"pair\">\n          <span class=\"node end\" style=\"--i:6\"><b>\u2193 Pain<\/b><small>analgesic<\/small><\/span>\n          <span class=\"node end\" style=\"--i:6\"><b>\u2193 Fever<\/b><small>antipyretic<\/small><\/span>\n        <\/div>\n      <\/div>\n    <\/div>\n\n    <div class=\"cards c3\" style=\"margin-top:56px\">\n      <article class=\"card rv\" style=\"--d:0\">\n        <div class=\"card-h\"><span class=\"ico\"><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\"><circle cx=\"12\" cy=\"12\" r=\"9\"\/><path d=\"M12 7v5l3 2\"\/><\/svg><\/span><h3>Dosage and Administration<\/h3><\/div>\n        <ul><li>For adults and adolescents over 15 years: 1g of Metamizole administered IM or IV.<\/li><li>The dose may be repeated every 6 to 8 hours as needed, not exceeding 4g\/day.<\/li><li>For intravenous administration, inject very slowly, at a rate not exceeding 1 mL per minute.<\/li><li>OPC ampoules should be opened at a predetermined point, ensuring safer and more efficient opening.<\/li><\/ul>\n      <\/article>\n      <article class=\"card rv\" style=\"--d:1\">\n        <div class=\"card-h\"><span class=\"ico\"><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\"><path d=\"M10 3h4v3l1 2v12a1 1 0 0 1-1 1h-4a1 1 0 0 1-1-1V8l1-2V3Z\"\/><\/svg><\/span><h3>New OPC Ampoules<\/h3><\/div>\n        <ul><li>Reduced particle emission upon opening. Enamel flakes from the ceramic rings can no longer fall into the medication.<\/li><li>Cleaner break appearance, reduced risk of sharp glass spikes when opening, reducing the risk of injury.<\/li><li>Significant reduction in the risk of ampoules that are very difficult to open.<\/li><\/ul>\n      <\/article>\n      <article class=\"card rv\" style=\"--d:2\">\n        <div class=\"card-h\"><span class=\"ico\"><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\"><path d=\"M9 3h6M10 3v6l-5 9a2 2 0 0 0 1.800 3h10.400a2 2 0 0 0 1.800-3l-5-9V3\"\/><path d=\"M7.500 15h9\"\/><\/svg><\/span><h3>Clinical Considerations<\/h3><\/div>\n        <ul><li>Use with caution in patients with a history of allergies to analgesics.<\/li><li>Monitor blood pressure during intravenous administration, as it may cause hypotension.<\/li><li>Avoid in patients with acute hepatic porphyria, glucose-6-phosphate dehydrogenase deficiency, a history of metamizole-induced agranulocytosis, impaired bone marrow function, or diseases of the hematopoietic system.<\/li><\/ul>\n      <\/article>\n    <\/div>\n  <\/div>\n<\/section>\n\n<section class=\"note\" aria-labelledby=\"imp\">\n  <div class=\"cx-wrap\">\n    <div class=\"note-box has-bg rv\" style=\"--ov:9,52,46\">\n      <div class=\"bg\" aria-hidden=\"true\"><img loading=\"lazy\" src=\"https:\/\/crassulapharma.com\/wp-content\/uploads\/2026\/10\/info-novapyr.jpg\" alt=\"\" width=\"1600\" height=\"1200\" loading=\"lazy\" decoding=\"async\" title=\"\"><\/div>\n      <h3 id=\"imp\"><span class=\"ico\"><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\"><path d=\"M12 3 2.500 20h19L12 3Z\"\/><path d=\"M12 10v4.500M12 17.200v.1\"\/><\/svg><\/span>Safety and Precautionary Measures<\/h3>\n      <ul>\n        <li>If symptoms of agranulocytosis occur, discontinue treatment and perform a blood count immediately.<\/li>\n        <li>Caution in patients with renal or hepatic disease.<\/li>\n        <li>Contraindicated in patients during the third trimester of pregnancy and in those with hypersensitivity to metamizole.<\/li>\n      <\/ul>\n    <\/div>\n  <\/div>\n<\/section>\n\n<section class=\"faq\" id=\"faq\" aria-labelledby=\"faq-h\">\n  <div class=\"cx-wrap\">\n    <h2 class=\"h2 rv\" id=\"faq-h\">Frequently Asked Questions<\/h2>\n    <div class=\"faq-list\">\n      <div class=\"faq-item rv\" style=\"--d:0\">\n        <h3><button class=\"faq-q\" type=\"button\" id=\"faq-q1\" aria-expanded=\"false\" aria-controls=\"faq-a1\"><span>What is Novapyr?<\/span><span class=\"faq-ico\" aria-hidden=\"true\"><svg viewBox=\"0 0 16 16\"><path d=\"M8 2v12M2 8h12\"\/><\/svg><\/span><\/button><\/h3>\n        <div class=\"faq-a\" id=\"faq-a1\" role=\"region\" aria-labelledby=\"faq-q1\"><div><p><strong>Novapyr<\/strong> 1g\/2ml (Metamizole Sodium) for Intramuscular and Intravenous Use with OPC Ampoule. Novapyr 1g\/2ml is an injectable solution of Metamizole Sodium, presented in OPC (One-Point-Cut) ampoules for intramuscular (IM) and intravenous (IV) administration. This analgesic and antipyretic is highly effective for the management of severe pain and the control of high fevers, particularly in situations where other treatments have not been effective.<\/p><\/div><\/div>\n      <\/div>\n      <div class=\"faq-item rv\" style=\"--d:1\">\n        <h3><button class=\"faq-q\" type=\"button\" id=\"faq-q2\" aria-expanded=\"false\" aria-controls=\"faq-a2\"><span>What is Novapyr indicated for?<\/span><span class=\"faq-ico\" aria-hidden=\"true\"><svg viewBox=\"0 0 16 16\"><path d=\"M8 2v12M2 8h12\"\/><\/svg><\/span><\/button><\/h3>\n        <div class=\"faq-a\" id=\"faq-a2\" role=\"region\" aria-labelledby=\"faq-q2\"><div><p>Metamizole 1g\/2ml is indicated for the treatment of: severe acute pain (postoperative, post-traumatic, renal colic and biliary colic), cancer pain (management of pain associated with oncological diseases) and high fever that does not respond to other antipyretics.<\/p><\/div><\/div>\n      <\/div>\n      <div class=\"faq-item rv\" style=\"--d:2\">\n        <h3><button class=\"faq-q\" type=\"button\" id=\"faq-q3\" aria-expanded=\"false\" aria-controls=\"faq-a3\"><span>How does Novapyr work?<\/span><span class=\"faq-ico\" aria-hidden=\"true\"><svg viewBox=\"0 0 16 16\"><path d=\"M8 2v12M2 8h12\"\/><\/svg><\/span><\/button><\/h3>\n        <div class=\"faq-a\" id=\"faq-a3\" role=\"region\" aria-labelledby=\"faq-q3\"><div><p>Metamizole is a pyrazolone derivative with potent analgesic and antipyretic effects. It acts by inhibiting the synthesis of prostaglandins and other mediators of pain and fever in the central and peripheral nervous system.<\/p><\/div><\/div>\n      <\/div>\n      <div class=\"faq-item rv\" style=\"--d:3\">\n        <h3><button class=\"faq-q\" type=\"button\" id=\"faq-q4\" aria-expanded=\"false\" aria-controls=\"faq-a4\"><span>How is Novapyr dosed and administered?<\/span><span class=\"faq-ico\" aria-hidden=\"true\"><svg viewBox=\"0 0 16 16\"><path d=\"M8 2v12M2 8h12\"\/><\/svg><\/span><\/button><\/h3>\n        <div class=\"faq-a\" id=\"faq-a4\" role=\"region\" aria-labelledby=\"faq-q4\"><div><p>For adults and adolescents over 15 years: 1g of Metamizole administered IM or IV. The dose may be repeated every 6 to 8 hours as needed, not exceeding 4g\/day. For intravenous administration, inject very slowly, at a rate not exceeding 1 mL per minute. OPC ampoules should be opened at a predetermined point, ensuring safer and more efficient opening.<\/p><\/div><\/div>\n      <\/div>\n      <div class=\"faq-item rv\" style=\"--d:4\">\n        <h3><button class=\"faq-q\" type=\"button\" id=\"faq-q5\" aria-expanded=\"false\" aria-controls=\"faq-a5\"><span>What are the New OPC Ampoules?<\/span><span class=\"faq-ico\" aria-hidden=\"true\"><svg viewBox=\"0 0 16 16\"><path d=\"M8 2v12M2 8h12\"\/><\/svg><\/span><\/button><\/h3>\n        <div class=\"faq-a\" id=\"faq-a5\" role=\"region\" aria-labelledby=\"faq-q5\"><div><p>Reduced particle emission upon opening. Enamel flakes from the ceramic rings can no longer fall into the medication. Cleaner break appearance, reduced risk of sharp glass spikes when opening, reducing the risk of injury. Significant reduction in the risk of ampoules that are very difficult to open.<\/p><\/div><\/div>\n      <\/div>\n      <div class=\"faq-item rv\" style=\"--d:4\">\n        <h3><button class=\"faq-q\" type=\"button\" id=\"faq-q6\" aria-expanded=\"false\" aria-controls=\"faq-a6\"><span>What are the clinical considerations for Novapyr?<\/span><span class=\"faq-ico\" aria-hidden=\"true\"><svg viewBox=\"0 0 16 16\"><path d=\"M8 2v12M2 8h12\"\/><\/svg><\/span><\/button><\/h3>\n        <div class=\"faq-a\" id=\"faq-a6\" role=\"region\" aria-labelledby=\"faq-q6\"><div><p>Use with caution in patients with a history of allergies to analgesics. Monitor blood pressure during intravenous administration, as it may cause hypotension. Avoid in patients with acute hepatic porphyria, glucose-6-phosphate dehydrogenase deficiency, a history of metamizole-induced agranulocytosis, impaired bone marrow function, or diseases of the hematopoietic system.<\/p><\/div><\/div>\n      <\/div>\n      <div class=\"faq-item rv\" style=\"--d:4\">\n        <h3><button class=\"faq-q\" type=\"button\" id=\"faq-q7\" aria-expanded=\"false\" aria-controls=\"faq-a7\"><span>What are the safety and precautionary measures for Novapyr?<\/span><span class=\"faq-ico\" aria-hidden=\"true\"><svg viewBox=\"0 0 16 16\"><path d=\"M8 2v12M2 8h12\"\/><\/svg><\/span><\/button><\/h3>\n        <div class=\"faq-a\" id=\"faq-a7\" role=\"region\" aria-labelledby=\"faq-q7\"><div><p>If symptoms of agranulocytosis occur, discontinue treatment and perform a blood count immediately. Caution in patients with renal or hepatic disease. Contraindicated in patients during the third trimester of pregnancy and in those with hypersensitivity to metamizole.<\/p><\/div><\/div>\n      <\/div>\n      <div class=\"faq-item rv\" style=\"--d:4\">\n        <h3><button class=\"faq-q\" type=\"button\" id=\"faq-q8\" aria-expanded=\"false\" aria-controls=\"faq-a8\"><span>Which strength and presentation is available?<\/span><span class=\"faq-ico\" aria-hidden=\"true\"><svg viewBox=\"0 0 16 16\"><path d=\"M8 2v12M2 8h12\"\/><\/svg><\/span><\/button><\/h3>\n        <div class=\"faq-a\" id=\"faq-a8\" role=\"region\" aria-labelledby=\"faq-q8\"><div><p>Novapyr contains Metamizole sodium BP 1 G \/ 2 ml. It is presented in a box of 10 and 100 ampoules, following the British Pharmacopoeia standard.<\/p><\/div><\/div>\n      <\/div>\n      <div class=\"faq-item rv\" style=\"--d:4\">\n        <h3><button class=\"faq-q\" type=\"button\" id=\"faq-q9\" aria-expanded=\"false\" aria-controls=\"faq-a9\"><span>How is Novapyr manufactured?<\/span><span class=\"faq-ico\" aria-hidden=\"true\"><svg viewBox=\"0 0 16 16\"><path d=\"M8 2v12M2 8h12\"\/><\/svg><\/span><\/button><\/h3>\n        <div class=\"faq-a\" id=\"faq-a9\" role=\"region\" aria-labelledby=\"faq-q9\"><div><p>Manufactured according to the strict specifications of the British Pharmacopoeia to ensure consistency and superior quality. Crassula Pharma certifies that all our products are manufactured in accordance with GMP parameters.<\/p><\/div><\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/section>\n\n<section class=\"quality\" id=\"quality\" aria-labelledby=\"qs\">\n  <div class=\"cx-wrap\">\n    <div class=\"qbox rv\">\n      <h2 id=\"qs\">Quality &amp; Standards<\/h2>\n      <div class=\"qgrid\">\n        <img decoding=\"async\" class=\"gmp\" src=\"https:\/\/crassulapharma.com\/wp-content\/uploads\/2026\/10\/logo-gmp.png\" alt=\"GMP Certified Quality\" width=\"112\" height=\"112\" title=\"\">\n        <div class=\"check\"><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\"><circle cx=\"12\" cy=\"12\" r=\"9.5\"\/><path d=\"m8 12.5 2.7 2.7L16 9.5\"\/><\/svg><p>Manufactured according to the strict specifications of the British Pharmacopoeia to ensure consistency and superior quality.<\/p><\/div>\n        <div class=\"check\"><svg viewBox=\"0 0 24 24\" aria-hidden=\"true\"><circle cx=\"12\" cy=\"12\" r=\"9.5\"\/><path d=\"m8 12.5 2.7 2.7L16 9.5\"\/><\/svg><p>Crassula Pharma certifies that all our products are manufactured in accordance with GMP parameters.<\/p><\/div>\n      <\/div>\n    <\/div>\n  <\/div>\n<\/section>\n<\/main>\n\n\n<script>\n(function(){\n  var d=document.documentElement,b=document.body;\n  b.classList.remove('no-js');\n  requestAnimationFrame(function(){requestAnimationFrame(function(){b.classList.add('loaded')})});\n\n  var io=new IntersectionObserver(function(es){es.forEach(function(e){\n    if(e.isIntersecting){e.target.classList.add('in');io.unobserve(e.target)}})},{threshold:.15,rootMargin:'0px 0px -6% 0px'});\n  document.querySelectorAll('.rv').forEach(function(el){io.observe(el)});\n\n\n  (function(){\n    var c=document.getElementById('fx');if(!c||!c.getContext)return;\n    var ctx=c.getContext('2d'),hero=c.parentElement,W=0,H=0,dpr=1,P=[],run=false,raf=0,mx=-999,my=-999;\n    var reduce=matchMedia('(prefers-reduced-motion: reduce)').matches;\n    function size(){var r=hero.getBoundingClientRect();dpr=Math.min(devicePixelRatio||1,2);W=r.width;H=r.height;c.width=W*dpr;c.height=H*dpr;ctx.setTransform(dpr,0,0,dpr,0,0);\n      var n=Math.round(Math.min(90,Math.max(28,W*H\/16000)));P=[];\n      for(var i=0;i<n;i++)P.push({x:Math.random()*W,y:Math.random()*H,vx:(Math.random()-.5)*.28,vy:(Math.random()-.5)*.28,r:Math.random()*1.4+.8});}\n    function draw(){\n      ctx.clearRect(0,0,W,H);var L=Math.min(150,W\/7);\n      for(var i=0;i<P.length;i++){var a=P[i];\n        if(!reduce){a.x+=a.vx;a.y+=a.vy;if(a.x<0||a.x>W)a.vx*=-1;if(a.y<0||a.y>H)a.vy*=-1;\n          var dx=a.x-mx,dy=a.y-my,d=dx*dx+dy*dy;if(d<14400){var f=(1-Math.sqrt(d)\/120)*.6;a.x+=dx*f*.02;a.y+=dy*f*.02}}\n        for(var j=i+1;j<P.length;j++){var b=P[j],ex=a.x-b.x,ey=a.y-b.y,e=ex*ex+ey*ey;\n          if(e<L*L){ctx.strokeStyle='rgba(224,196,236,'+(.22*(1-Math.sqrt(e)\/L))+')';ctx.lineWidth=1;ctx.beginPath();ctx.moveTo(a.x,a.y);ctx.lineTo(b.x,b.y);ctx.stroke()}}\n        ctx.fillStyle='rgba(240,222,247,.75)';ctx.beginPath();ctx.arc(a.x,a.y,a.r,0,6.2832);ctx.fill();}\n      if(run&&!reduce)raf=requestAnimationFrame(draw);}\n    function start(){if(!run){run=true;raf=requestAnimationFrame(draw)}}\n    function stop(){run=false;cancelAnimationFrame(raf)}\n    size();draw();\n    var rt;addEventListener('resize',function(){clearTimeout(rt);rt=setTimeout(function(){size();draw()},150)});\n    hero.addEventListener('pointermove',function(e){var r=hero.getBoundingClientRect();mx=e.clientX-r.left;my=e.clientY-r.top},{passive:true});\n    hero.addEventListener('pointerleave',function(){mx=my=-999});\n    new IntersectionObserver(function(es){es[0].isIntersecting?start():stop()}).observe(hero);\n  })();\n\n  document.querySelectorAll('.faq-q').forEach(function(b){\n    b.addEventListener('click',function(){\n      var it=b.closest('.faq-item'),open=it.classList.toggle('open');\n      b.setAttribute('aria-expanded',open?'true':'false');\n    });\n  });\n  var flow=document.getElementById('flow');\n  var fio=new IntersectionObserver(function(es){es.forEach(function(e){if(e.isIntersecting){flow.classList.add('in');fio.disconnect()}})},{threshold:.25});\n  fio.observe(flow);\n\n  var steps=document.getElementById('steps');\n  function line(){var r=steps.getBoundingClientRect(),h=innerHeight;\n    var p=Math.min(1,Math.max(0,(h*.75-r.top)\/r.height));steps.style.setProperty('--line',p)}\n  addEventListener('scroll',line,{passive:true});line();\n\n})();\n<\/script>\n<\/body>\n<\/html>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Novapyr\u00ae (Metamizole sodium) \u2013 Crassula Skip to content Analgesic \u00b7 Antipyretic \u00b7 Injectable Solution I.M. \/ I.V. Novapyr\u00ae Metamizole sodium 1G \/ 2 ml Pharmacological Properties Active ingredient Metamizole sodium BP Strength 1 G \/ 2 ml Presentation Box of 10 and 100 ampoules Standard British Pharmacopoeia What is Novapyr? Novapyr 1g\/2ml (Metamizole Sodium) for [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","_uf_show_specific_survey":0,"_uf_disable_surveys":false,"footnotes":""},"class_list":["post-11984","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/crassulapharma.com\/es\/wp-json\/wp\/v2\/pages\/11984","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/crassulapharma.com\/es\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/crassulapharma.com\/es\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/crassulapharma.com\/es\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/crassulapharma.com\/es\/wp-json\/wp\/v2\/comments?post=11984"}],"version-history":[{"count":4,"href":"https:\/\/crassulapharma.com\/es\/wp-json\/wp\/v2\/pages\/11984\/revisions"}],"predecessor-version":[{"id":11990,"href":"https:\/\/crassulapharma.com\/es\/wp-json\/wp\/v2\/pages\/11984\/revisions\/11990"}],"wp:attachment":[{"href":"https:\/\/crassulapharma.com\/es\/wp-json\/wp\/v2\/media?parent=11984"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}